مقاله مشترک آقای دکتر دهپور (مرکز تحقیقات طب تجربی) با دکتر Ethan A. LERNER از كشور آمريكا در Pubmed تحت عنوان: "Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice.


۳۰ بهمن ۱۳۹۵

دومین مقاله حاصل کار مشترک آقای دکتر دهپور (مرکز تحقیقات طب تجربی) با دکتر  Ethan A. LERNER از  Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, USA   در Pubmed قابل مشاهده است. این کار در زمینه مکانیسم های ایجاد خارش در مدل های تجربی می باشد.

 

Acta Derm Venereol. 2017 Jan 25. doi: 10.2340/00015555-2617. [Epub ahead of print]

Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice.

Haddadi NS, Foroutan A, Ostadhadi S, Azimi E, Rahimi N, Nateghpour M, Lerner EA, Dehpour AR.

 

Intradermal administration of chloroquine (CQ) provokes scratching behavior in mice. Chloroquine-induced itch is histamine-independent and we have reported that the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway is involved in CQ-induced scratching behavior in mice. Previous studies have demonstrated that activation of N-methyl-d-aspartate receptors (NMDARs) induces NO production. Here we show that NMDAR antagonists significantly decrease CQ-induced scratching in mice while a non-effective dose of an NMDAR agonist potentiates the scratching behavior provoked by sub-effective doses of CQ. In contrast, combined pre-treatment with sub-effective doses of an NMDAR antagonist, MK-801, and the NO synthase inhibitor, L-N-nitro arginine methyl ester (L-NAME), decreases CQ-induced scrat-ching behavior. While intradermal administration of CQ significantly increases the concentration of intradermal nitrite, the end product of NO metabolism, effective doses of intraperitoneal and intradermal MK-801 significantly decrease intradermal nitrite levels. Likewise, administration of an effective dose of L-NAME significantly decreases CQ-induced nitrite production. We conclude that the NMDA/NO pathway in the skin modulates CQ-induced scratching behavior.


Exp Dermatol. 2016 May;25(5):340-3. doi: 10.1111/exd.12935. Epub 2016 Feb 26.

Are itch and scratching the nausea and vomiting of skin?

Ostadhadi S, Azimi E, Lerner EA, Dehpour AR.

 

The physiologic similarities between itch and nausea may not be evident initially, but they share the role of repelling irritants and toxins from the body by inducting scratching and vomiting, respectively. In addition, itch and nausea frequently occur together in certain conditions such as uraemia. Here we show that the mechanisms underlying itch and nausea overlap and that advances in either field may influence the identification of novel drug targets, particularly for itch.



منبع: گروه فارماکولوژي دانشکده پزشکي