بررسی سطح سرمی خون در کارگران یک کارخانه باتریسازی و ارتباط آن با نتایج تست های عصبی-رفتاری در سال

بررسی سطح سرمی خون در کارگران یک کارخانه باتریسازی و ارتباط آن با نتایج تست های عصبی-رفتاری در سال

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سرب یکی از فلزاتی است که ترکیبات آن نقش مهمی در صنعت دارند. و لذا در این مطالعه برای تعیین سطح سرمی سرب در کارگران کارخانه تولید باطری و ارتباط آن با عملکرد عصبی رفتاری یک مطالعه مقطعی طراحی شد.
روش اجرا: در این مطالعه، 154 نفر از کارگران یک کارخانه باطری سازی شرکت نمودند. نمونه خون آنها برای اندازه گیری سطح سرمی سرب خون جمع آوری شده و سپس با روش جذب اتمی اندازه گیری شد.  تست های عصبی رفتاری استفاده شده ، سه  مورد از تستهای، عملکردی عصبی رفتاری تایید شده توسط سازمان بهداشت جهانی شامل،  زمان واکنش ساده (SRT)، تست حافظه بینایی بنتون (BVRT) و آزمون پوردو پگبورد یا Santa Ana  بودند.
يافته ها: بين طول مدت اشتغال کارگران در کارخانه و سطح سرمی سرب رابطه معني دار آماري وجود داشت (P = 0.02) . بین آزمونهای پوردو پگبورد و تست حافظه بینایی بنتون و مدت کار درکارخانه ارتباط معنی دار آماری  وجود داشت (001/0 (P=
نتيجه گيري: در اين مطالعه، بين سطوح سرمي خون و سال هاي استخدام، و همچنين بين آزمون بينايی بنتون و سطح خون سرم همبستگی منفی وجود دارد. نتایج این مطالعه نشان می دهد که قرار گرفتن در معرض سرب می تواند باعث اختلالات عصبی رفتاری در کارگران کارخانه تولیدکننده باتری شود.
 
 
 
 

 
كليد واژه ها : سرب، مواجهه شغلی، عصبی- رفتاری
مشخصات دانشجو:
نام:  عباسعلی صانعیان  رشته تحصيلي:  طب کار  مقطع: دستیاری تخصصی                   گروه آموزشي: طب کار            پست الكترونيك دانشجو:
Sanali1347@gmail.com
اساتيد راهنما و داور:
استاد راهنما :دکتر امید امینیان    استاد مشاور : دکتر نازنین ایزدی   اساتيد داور: دکتر رامین مهرداد ،  دکتر پوریعقوب، دکتر مریم سرایی، دکتر سحر افتخاری.
زمان دفاع :
   روز   تاريخ  ساعت: ساعت 14 10/02/97
مكان دفاع به آدرس:
خیابان پورسینا دانشکده پزشکی گروه طب کار اطاق کنفرانس گروه
اطلاعات به زبان انگليسي
Title: Serum Lead Assessment in battery manufacturing workers and Relationship with NCTB-WHO Tests
 
 
 
Abstract: Object: We Aimed to find out association between neurobehavioral performances and serum lead level in battery manufacturing workers.
Background: Lead is one of the metals that its compounds play an important role in the industry. The effect of lead on human health has always been one of the concerns of medical circles and one of the most important systems affected by lead is the nervous system  
 Methods & Materials: We designed a cross-sectional study.  One hundred and fifty four workers working in a battery factory participated in this study. Sample was also collected from venous blood for measuring blood lead serum level, then it was measured by atomic absorption. Three of the selected tests of neuropsychological performance approved by the World Health Organization were conducted including Simple Reaction Time (SRT), Benton Visual Retention Test (BVRT) and Santa Ana manual dexterity test.
Results: There was a significant statistical relationship between employment duration of workers at the factory and serum lead levels (P = 0.02). Right Purdue pegboard and Benton visual tests had a significant relationship with the duration of work in the factory (P = 0.001).
Conclusions: In this study, there was a negative correlation between blood lead levels and years of employment, and also between Benton visual test and serum blood levels. The results of this study suggest that occupational exposure to lead could induce a neurobehavioral deficiency in battery manufacturing workers
Keywords: : lead, battery manufacturing,  neurobehavioral performances
 
 
 
فهرست منابع:
1. Han DY, Hoelzle JB, Dennis BC, Hoffmann M. A brief review of cognitive assessment in neurotoxicology. Neurologic clinics. 2011;29(3):581-90.
2. Mason LH, Mathews MJ, Han DY. Neuropsychiatric symptom assessments in toxic exposure. Psychiatric Clinics of North America. 2013;36(2):201-8.
3. Brochin R, Leone S, Phillips D, Shepard N, Zisa D, Angerio A. The Cellular Effect of Lead Poisioning and Its Clinical Picture. Issues. 2008;5(2).
4. Basha DC, Reddy NS, Rani MU, Reddy GR. Age related changes in aminergic system and behavior following lead exposure: protection with essential metal supplements. Neuroscience research. 2014;78:81-9.
5. Szczerbak G, Nowak P, Kostrzewa RM, Brus R. Maternal lead exposure produces long-term enhancement of dopaminergic reactivity in rat offspring. Neurochemical research. 2007;32(10):1791-8.
6. Leret M, Garcia-Uceda F, Antonio M. Effects of maternal lead administration on monoaminergic, GABAergic and glutamatergic systems. Brain research bulletin. 2002;58(5):469-73.
7. Carta P, Carta R, Aru G, Polizzi M, Gaviano L, Salis S, et al. Neurobehavioural testing in lead smelter workers. Giornale italiano di medicina del lavoro ed ergonomia. 2004;27(3):285-9.
8. Niu Q, He S, Li H, Wang J, Dai F, Chen Y. A comprehensive neurobehavioral and neurophysiological study for low level lead-exposed workers. Giornale italiano di medicina del lavoro ed ergonomia. 1999;22(4):299-304.
9. Muzi G, Murgia N, Dell'Omo M, Fiordi T, Sposini F, Argentino A, et al. Effects of inorganic lead exposure on the autonomic nervous system and on the variability of heart rate among workers at a battery plant. Giornale italiano di medicina del lavoro ed ergonomia. 2004;27:46-50.
10. Jeyaratnam J, Boey K, Ong C, Chia C, Phoon W. Neuropsychological studies on lead workers in Singapore. British journal of industrial medicine. 1986;43(9):626-9.
11. Chen S-S, Chen T-J, Lin C-H, Tseng Y-T, Lai S-L. Neurobehavioral changes in Taiwanese lead-exposed workers. Journal of occupational and environmental medicine. 2005;47(9):902-8.
12. Chertkow H, Massoud F, Nasreddine Z, Belleville S, Joanette Y, Bocti C, et al. Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia. Canadian Medical Association Journal. 2008;178(10):1273-85.
13. Rapisarda V, Ledda C, Ferrante M, Fiore M, Cocuzza S, Bracci M, et al. Blood pressure and occupational exposure to noise and lead (Pb) A cross-sectional study. Toxicology and industrial health. 2016;32(10):1729-36.
14. Aminian O, Izadi N, Esmaeili A, Emami SM. Neurobehavioral Effects of Occupational Exposure to Organic Solvents among Pharmaceutical Laboratory Workers in Iran. International Journal of Health Studies. 2016;2(2).
15. Fenga C, Gangemi S, Alibrandi A, Costa C, Micali E. Relationship between lead exposure and mild cognitive impairment. Journal of Preventive Medicine and Hygiene. 2016;57(4):E205.
16. Sadeghniiat-Haghighi K, Yousefian M, Aminian O, Najafi A. Association between Blood Lead Level and Sleep Quality in Lead-Zinc Factories in Zanjan: A Cross-Sectional Study. Journal of Sleep Sciences. 2015;1(1):18-22.
17. Ravibabu K, Barman T, Rajmohan H. Serum neuron-specific enolase, biogenic amino-acids and neurobehavioral function in lead-exposed workers from lead-acid battery manufacturing process. The international journal of occupational and environmental medicine. 2015;6(1 January):436-50-7.
18. Hou S, Yuan L, Jin P, Ding B, Qin N, Li L, et al. A clinical study of the effects of lead poisoning on the intelligence and neurobehavioral abilities of children. Theoretical Biology and Medical Modelling. 2013;10(1):13.
19. Hänninen H, Aitio A, Kovala T, Luukkonen R, Matikainen E, Mannelin T, et al. Occupational exposure to lead and neuropsychological dysfunction. Occupational and environmental medicine. 1998;55(3):202-9.
20. H. Reihani Kermani AN. the relationship between blood lead concentration and electroneuromyographic findings in lead-exosed subjects. the Journal of Qazvin University of Medical school. 2004;33:27-33.
21. Ahmad Abdolmalki AA, S Abas Bagheri Yazdi, Masoumeh Nosrati, Maryam Hamedani, Ali Mohamadi. Study of lead  effects on the mental health of tin laborers in a car making company of  Tehran city 2007 Iran Occupational Health. 2009;6 (2):26-30.
22. Balbus JM, Stewart W, Bolla KI, Schwartz BS. Simple visual reaction time in organolead manufacturing workers: comparison of different methods of modeling lead exposure and reaction time. American journal of industrial medicine. 1997;32(5):544-9.
23. Winker R, Ponocny-Seliger E, Rüdiger H, Barth A. Lead exposure levels and duration of exposure absence predict neurobehavioral performance. International archives of occupational and environmental health. 2006;79(2):123-7.
24. Aminian O, Chavoshi F, Bahaedini LS, Soltani S, Najarkolaei FR. Relationship between blood lead level and male reproductive hormones in male lead exposed workers of a battery factory: A cross-sectional study. Iranian journal of reproductive medicine. 2013;11(8):673.

 

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