Thesis Progress Report Presentation

19 Jun 2019

Sumatriptan is the first clinically available triptan used to treat migraine, a selective agonist of serotonin 5-hydroxytryptamine 1b/1d receptor. To date the mechanism of the neuroprotection offered by sumatriptan in neurodegenerative diseases is unclear. The present study aimed to evaluate the possible involvement of NMDA, NO and ERK signaling in the neuroprotective effect of sumatriptan by in vivo and in vitro study models. The anticonvulsant activity was evaluated by using pentylenetetrazole (PTZ) induced seizure model. For this purpose, various doses of sumatriptan were administered in NMRI mice. The possible role of NMDA/NO pathway in PTZ induced generalized clonic seizures (GCS) was determined by using NMDA, MK-801, L-NAME, 7-NI, L-ARG and MB. The neuroprotection against glutamate induced cerebellar toxicity was evaluated through cerebellar granule neurons (CGNs) culture studies. Neuronal cell viability was checked by neutral red assay and MTT assay respectively. Nitrite assay by griess reaction was performed to measure nitric oxide levels. Results of study showed that sumatriptan attenuated significantly (p˂0.001) PTZ induced clonic seizure and glutamate toxicity. In conclusion, data of this study demonstrated that sumatriptan could be considered as a neuroprotective agent by acting through NMDA/NO pathway.

PhD of Pharmacology Seminar

29 Apr 2019

MSC of Toxicology Seminar

27 Apr 2019

Alzheimer’s disease (AD) is one of the most common forms of dementia. Despite a wealth of knowledge on the molecular mechanisms involved in AD, current treatments have mainly focused on targeting amyloid b (Ab) production, but have failed to show significant effects and efficacy. Therefore, a critical reconsideration of the multifactorial nature of the disease is needed. AD is a complex multifactorial disorder in which, along with Ab and tau, the convergence of polygenic, epigenetic, environmental, vascular, and metabolic factors increases the global susceptibility to the disease and shapes its course. One of the cofactors converging on AD is the dysregulation of brain metals. In this review, we focus on the role of AD-related neurodegeneration and cognitive decline triggered by the imbalance of two endogenous metals: copper and zinc. Saeid BabaAhmadi Supervisor: Dr.Shafaroodi Sunday 8/2/1398 14:30

The effect of cyclosporine A and calcineurin on morphine tolerance In the in vitro model PhD Thesis Defense Session

16 Jan 2019

isolated vascular response chronic endotoxemic

12 Jan 2019

Progress of thesis In vitro evaluation metformin morphine methadone tolerance through mTOR signaling pathway

4 Aug 2018

PhD thesis pre-defense session

3 Oct 2018

In vitro evaluation of effects of metformin on morphine and methadone tolerance through mTOR signaling pathway

19 Sep 2018

Investigation the protective effects of spermidine and curcumin nanomicelles in a rat model of cirrhotic cardiomyopathy induced by bile duct ligation

24 Jul 2018
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